An insulated cold box is a passive cooling container specifically designed to maintain a consistent low temperature for an extended period, making it indispensable for the safe transport and temporary storage of temperature-sensitive medical products, such as vaccines, pharmaceuticals, and laboratory samples, especially in areas where refrigeration is unavailable or unreliable. These boxes are constructed with high-quality insulation materials, such as polyurethane foam, injected between durable inner and outer walls, which effectively minimize heat transfer from the environment to the contents. They come in various sizes, ranging from small personal carriers to large transport containers. To maintain the cold temperature, pre-conditioned ice packs or gel packs are strategically placed inside with the products. Many models are designed for robust use, with features like strong latches, reinforced hinges, and ergonomic handles for easy transport. The effectiveness of an insulated cold box is measured by its "cold life," which is the duration it can maintain the internal temperature within the required range. Proper pre-conditioning of the coolants and careful packing of the contents are crucial to maximizing its cold life, ensuring the integrity and efficacy of vital medical supplies during their journey through the cold chain.